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Thetransformation ofMoPs to monocytes takes about 55 hours,and the monocytes remain in the circulation for only about16 hours before emigrating to the tissues where they differ-entiate under influence of both GM-CSF and M-CSF intotissue macrophages. Petitjean A, Mathe E, Kato S (2007) Impact of mutant p53 functional properties on TP53mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53database.

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